Irreversible opiate agonists and antagonists: the 14- hydroxydihydromorphinone azines

  title={Irreversible opiate agonists and antagonists: the 14- hydroxydihydromorphinone azines},
  author={E. Hahn and M. Carroll-Buatti and G. Pasternak},
  booktitle={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  • E. Hahn, M. Carroll-Buatti, G. Pasternak
  • Published in
    The Journal of neuroscience…
  • Biology, Medicine
  • Further investigations into the molecular actions of the 14- hydroxydihydromorphinone hydrazones (naloxazone, oxymorphazone, and naltrexazone) have suggested that their irreversible actions can be explained by the formation of their azines. These azines, naloxonazine, naltrexonazine, and oxymorphonazine, irreversibly block opiate binding in vitro 20- to 40-fold more potently than their corresponding hydrozones, naloxazone, naltrexazone, and oxymorphazone. The blockade of binding by naloxonazine… CONTINUE READING

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