Irreversible inflammation is associated with decreased levels of the alpha1-, beta1-, and alpha2-subunits of sGC in human odontoblasts.

@article{Korkmaz2011IrreversibleII,
  title={Irreversible inflammation is associated with decreased levels of the alpha1-, beta1-, and alpha2-subunits of sGC in human odontoblasts.},
  author={Y{\"u}ksel Korkmaz and Henk Lang and Thomas Beikler and B Cho and Soenke Behrends and Wilhelm Bloch and Klaus Addicks and Wolfgang H. M. Raab},
  journal={Journal of dental research},
  year={2011},
  volume={90 4},
  pages={517-22}
}
The nitric oxide (NO) receptor enzyme soluble guanylate cyclase (sGC) contains one prosthetic heme group as an αβ heterodimer, and two heterodimer isoforms (α(1)β(1), α(2)β(1)) were characterized to have enzyme activity. To test the irreversible inflammation-dependent regulation of sGC in odontoblasts, we incubated decalcified frozen sections of healthy and inflamed human third molars with antibodies against β-actin, nitrotyrosine, inducible nitric oxide synthase (iNOS), α(1)-, β(1)-, and α(2… CONTINUE READING