Irreversible electroporation: a novel pancreatic cancer therapy.

  title={Irreversible electroporation: a novel pancreatic cancer therapy.},
  author={Matthew J. Weiss and elliot k fishman},
  journal={Current problems in cancer},
  volume={37 5},

Figures from this paper

Irreversible electroporation of locally advanced pancreatic cancer.

Ireversible electroporation is an attractive ablative technique that changes the permeability of tumor cell membranes to induce apoptosis and has immunomodulatory effects, which may induce in vivo vaccination and may potentially synergize with immunotherapy.

Stage III pancreatic cancer and the role of irreversible electroporation

About a third of patients with pancreatic cancer present with locally advanced disease that is not amenable to resection. Because these patients have localized disease, conventional ablative

Ablative Therapies for Locally Advanced Pancreatic Cancer

The techniques, complications, and expected benefits of several ablative techniques as a treatment modality for locally advanced pancreatic cancer are described.

Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A Review

This study provides an up-to-date overview and a thematic summary of the current available evidence on the application of RFA and IRE on PDAC, together with a comparison of the two procedures.

Irreversible electroporation for the treatment of pancreatic neuroendocrine tumors

Ireversible electroporation for small tumors of the pancreas is practical and may offer advantages over other thermal ablative techniques, since it preserves vital structures such as blood vessels, bile and pancreatic ducts.

Percutaneous ablation of pancreatic cancer

The aim of this article will be to describe the multiple currently available treatment techniques (radiofrequency ablation, microwave ablation), their results, and their possible complications, with the aid of a literature review.

Electrochemotherapy in pancreatic adenocarcinoma treatment: pre-clinical and clinical studies

In order to increase the uptake of chemotherapeutic drugs into tumour cells, electrochemotherapy can be used for treatment of pancreatic adenocarcinoma leading to an increased tumour response rate.

Local ablation of pancreatic tumors: State of the art and future perspectives

In the management of patients with pancreatic cancer, the possibility of a multimodal approach should be considered, and conceptually, the combination of RFA with immunotherapy represents a novel angle of attack against this tumour.

Management of the Primary Tumor and Limited Metastases in Patients With Metastatic Pancreatic Cancer.

Guiding principles for local therapies to the primary intact pancreatic tumor for patients with limited metastatic disease and those who have had a significant response after systemic therapy are developed.

Irreversible Electroporation: A New Hope for the Pancreatic Cancer Patients

The grave situation with pancreatic cancer is illustrated in Figure 1 [1]. It shows that for the period of 1992-2011 [1], the number of incidences of new cases and the death are almost alike. This



Irreversible Electroporation in Locally Advanced Pancreatic Cancer: Potential Improved Overall Survival

IRE ablation of locally advanced pancreatic tumors remains safe and in the appropriate patient who has undergone standard induction therapy for a minimum of 4 months can achieve greater local palliation and potential improved overall survival compared with standard chemoradiation–chemotherapy treatments.

Chemoradiotherapy in the management of locally advanced pancreatic carcinoma: a qualitative systematic review.

No standard treatment exists, but there are two options for treatment of LAPC; these are gemcitabine-based chemotherapy and chemoradiotherapy which are not superior to chemotherapy in terms of survival and increases toxicity.

Tissue Ablation with Irreversible Electroporation

It is shown through mathematical analysis that irreversible electroporation can ablate substantial volumes of tissue, comparable to those achieved with other ablation techniques, without causing any detrimental thermal effects and without the need of adjuvant drugs.

Tumor Ablation with Irreversible Electroporation

The first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice was reported, and induced complete regression in 12 out of 13 treated tumors, in the absence of tissue heating.

Irreversible electroporation of the pancreas: Definitive local therapy without systemic effects

This study assessed the safety and ablation volume of IRE in porcine pancreatic tissue and found that IRE is a non‐thermal ablation technique that could allow ablation in the pancreas while preserving vital surrounding blood vessels.

In vivo results of a new focal tissue ablation technique: irreversible electroporation

Results of in vivo experiments that confirm the feasibility of a new minimally invasive method for tissue ablation, irreversible electroporation (IRE), and demonstrates that IRE can become an effective method for nonthermal tissueAblation requiring no drugs.