Irreversible caspase inhibitors: tools for studying apoptosis.

  title={Irreversible caspase inhibitors: tools for studying apoptosis.},
  author={Jacqueline Wu and Lawrence C. Fritz},
  volume={17 4},
Irreversible inhibitors of caspase proteases are often used in studies of apoptosis. However, vigorous interpretation of data generated with irreversible inhibitors requires quantitative analysis of their effects on enzyme kinetics. A simple method for the quantitative analysis of affinity irreversible inhibitors is introduced. The method allows simultaneous measurement of the dissociation constant Ki for the reversible binding to a caspase and the first-order rate constant k3 for the… CONTINUE READING

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