Irreversible binding of an anticancer compound (BI-94) to plasma proteins.

Abstract

1. We investigated the mechanisms responsible for the in vivo instability of a benzofurazan compound BI-94 (NSC228148) with potent anti-cancer activity. 2. BI-94 was stable in MeOH, water, and in various buffers at pHs 2.5-5, regardless of the buffer composition. In contrast, BI-94 was unstable in NaOH and at pHs 7-9, regardless of the buffer composition… (More)
DOI: 10.3109/00498254.2015.1025250

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Cite this paper

@article{Gautam2015IrreversibleBO, title={Irreversible binding of an anticancer compound (BI-94) to plasma proteins.}, author={Nagsen Gautam and Rhishikesh Thakare and Sandeep Rana and Amarnath Natarajan and Yazen M Alnouti}, journal={Xenobiotica; the fate of foreign compounds in biological systems}, year={2015}, volume={45 10}, pages={858-73} }