Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control

@article{Takahashi2007IrreversibilityOC,
  title={Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control},
  author={Akiko Takahashi and Naoko Ohtani and Eiji Hara},
  journal={Cell Division},
  year={2007},
  volume={2},
  pages={10 - 10}
}
The retinoblastoma (Rb) tumor suppressor gene product, pRb, has an established role in the implementation of cellular senescence, the state of irreversible G1 cell cycle arrest provoked by diverse oncogenic stresses. In murine cells, senescence cell cycle arrest can be reversed by subsequent inactivation of pRb, indicating that pRb is required not only for the onset of cellular senescence, but also for the maintenance of senescence program in murine cells. However, in human cells, once pRb is… CONTINUE READING

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