Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control

  title={Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control},
  author={Akiko Takahashi and Naoko Ohtani and Eiji Hara},
  journal={Cell Division},
  pages={10 - 10}
The retinoblastoma (Rb) tumor suppressor gene product, pRb, has an established role in the implementation of cellular senescence, the state of irreversible G1 cell cycle arrest provoked by diverse oncogenic stresses. In murine cells, senescence cell cycle arrest can be reversed by subsequent inactivation of pRb, indicating that pRb is required not only for the onset of cellular senescence, but also for the maintenance of senescence program in murine cells. However, in human cells, once pRb is… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 70 references

Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all

Nature Reviews Molecular Cell Biology • 2006
View 4 Excerpts
Highly Influenced

Cell cycle kinases in cancer.

Current opinion in genetics & development • 2007
View 1 Excerpt

Cellular senescence and cancer treatment.

Biochimica et biophysica acta • 2007
View 1 Excerpt

Divorcing ARF and p53: an unsettled case

Nature Reviews Cancer • 2006
View 1 Excerpt

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