Irreversibility in unbranched pathways: preferred positions based on regulatory considerations.

@article{Alves2001IrreversibilityIU,
  title={Irreversibility in unbranched pathways: preferred positions based on regulatory considerations.},
  author={Rui Alves and Michael A. Savageau},
  journal={Biophysical journal},
  year={2001},
  volume={80 3},
  pages={1174-85}
}
It has been observed experimentally that most unbranched biosynthetic pathways have irreversible reactions near their beginning, many times at the first step. If there were no functional reasons for this fact, then one would expect irreversible reactions to be equally distributed among all positions in such pathways. Since this is not the case, we have attempted to identify functional consequences of having an irreversible reaction early in the pathway. We systematically varied the position of… CONTINUE READING