Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture

@inproceedings{Asaithamby2011IrreparableCD,
  title={Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture},
  author={Aroumougame Asaithamby and Burong Hu and Oliver Delgado and Liang-hao Ding and Michael D. Story and John D. Minna and Jerry W Shay and David J. Chen},
  booktitle={Nucleic acids research},
  year={2011}
}
DNA damage and consequent mutations initiate the multistep carcinogenic process. Differentiated cells have a reduced capacity to repair DNA lesions, but the biological impact of unrepaired DNA lesions in differentiated lung epithelial cells is unclear. Here, we used a novel organotypic human lung three-dimensional (3D) model to investigate the biological significance of unrepaired DNA lesions in differentiated lung epithelial cells. We showed, consistent with existing notions that the kinetics… CONTINUE READING

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