Irradiation of existing atherosclerotic lesions increased inflammation by favoring pro-inflammatory macrophages.

@article{Gabriels2014IrradiationOE,
  title={Irradiation of existing atherosclerotic lesions increased inflammation by favoring pro-inflammatory macrophages.},
  author={Karen M R Gabriels and Saske Hoving and Marion J. J. Gijbels and Jeffrey F. C. Pol and Johannes A. M. te Poele and Erik A. L. Biessen and M J A P Daemen and Fiona A Stewart and Sylvia Heeneman},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2014},
  volume={110 3},
  pages={455-60}
}
BACKGROUND AND PURPOSE Recent studies have shown an increased incidence of localized atherosclerosis and subsequent cardiovascular events in cancer patients treated with thoracic radiotherapy. We previously demonstrated that irradiation accelerated the development of atherosclerosis and predisposed to an inflammatory plaque phenotype in young hypercholesterolemic ApoE(-/-) mice. However, as older cancer patients already have early or advanced stages of atherosclerosis at the time of… CONTINUE READING
12 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…