Irradiation of Juvenile, but not Adult, Mammary Gland Increases Stem Cell Self‐Renewal and Estrogen Receptor Negative Tumors

@article{Tang2014IrradiationOJ,
  title={Irradiation of Juvenile, but not Adult, Mammary Gland Increases Stem Cell Self‐Renewal and Estrogen Receptor Negative Tumors},
  author={Jonathan Tang and Ignacio Fernandez-Garcia and Sangeetha Vijayakumar and Haydeliz Martinez-Ruis and Irineu Illa-Bochaca and David Nguyen and Jian-Hua Mao and Sylvain V. Costes and Mary Helen Barcellos-Hoff},
  journal={STEM CELLS},
  year={2014},
  volume={32}
}
Children exposed to ionizing radiation have a substantially greater breast cancer risk than adults; the mechanism for this strong age dependence is not known. Here we show that pubertal murine mammary glands exposed to sparsely or densely ionizing radiation exhibit enrichment of mammary stem cell and Notch pathways, increased mammary repopulating activity indicative of more stem cells, and propensity to develop estrogen receptor (ER) negative tumors thought to arise from stem cells. We… 
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It is demonstrated that transduction of human breast luminal cells with hTERT/shp16 renders them immortal while remaining true to the luminal lineage including expression of functional ER (iHBECERpos), and proposed that iHBEC ERpos may serve to shed light on hitherto unappreciated differences in ER regulation and function between normal breast and breast cancer.
Densely ionizing radiation acts via the microenvironment to promote aggressive Trp53-null mammary carcinomas.
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The data suggest that carcinogenic effects of densely ionizing radiation are mediated by the microenvironment, which elicits more aggressive tumors compared with similar tumors arising in sham-irradiated hosts.
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