Irradiation inhibits the maturation and mineralization of osteoblasts via the activation of Nrf2/HO-1 pathway

  title={Irradiation inhibits the maturation and mineralization of osteoblasts via the activation of Nrf2/HO-1 pathway},
  author={Sung-Ho Kook and Kyoung-A Kim and Hyeok Ji and Daewoo Lee and J -J Lee},
  journal={Molecular and Cellular Biochemistry},
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates the induction of antioxidant gene expression and protects cells against oxidative injury. However, there are controversial findings regarding the roles of Nrf2 on bone metabolism under oxidative stress. The role of Nrf2 on the differentiation of radiation-exposed osteoblasts is also unclear. We investigated whether Nrf2 negatively or positively affects osteoblast differentiation in response to irradiation. Irradiation inhibited… CONTINUE READING


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