Irradiation-induced G2/M checkpoint response requires ERK1/2 activation

  title={Irradiation-induced G2/M checkpoint response requires ERK1/2 activation},
  author={Yujing Yan and Claudine P Black and Kenneth H. Cowan},
Following DNA damage, cells undergo G2/M cell cycle arrest, allowing time for DNA repair. G2/M checkpoint activation involves activation of Wee1 and Chk1 kinases and inhibition of Cdc25A and Cdc25C phosphatases, which results in inhibition of Cdc2 kinase. Results presented in this report indicate that γ-irradiation (IR) exposure of MCF-7 cells resulted in extracellular signal regulated protein kinase 1 and 2 (ERK1/2) activation and induction of G2/M arrest. Furthermore, inhibition of ERK1/2… CONTINUE READING
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