Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds.

@article{Newman2018IrradiationAS,
  title={Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds.},
  author={Alexandra A. C. Newman and Richard A. Baylis and Daniel L Hess and Steven Griffith and Laura S. Shankman and Olga A Cherepanova and Gary K. Owens},
  journal={JCI insight},
  year={2018},
  volume={3 15}
}
The long-term adverse effects of radiotherapy on cardiovascular disease are well documented. However, the underlying mechanisms responsible for this increased risk are poorly understood. Previous studies using rigorous smooth muscle cell (SMC) lineage tracing have shown abundant SMC investment into atherosclerotic lesions, where SMCs contribute to the formation of a protective fibrous cap. Studies herein tested whether radiation impairs protective adaptive SMC responses during vascular disease… 

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