Irradiated tumor cell vaccine for treatment of an established glioma. II. Expansion of myeloid suppressor cells that promote tumor progression

@article{Prins2002IrradiatedTC,
  title={Irradiated tumor cell vaccine for treatment of an established glioma. II. Expansion of myeloid suppressor cells that promote tumor progression},
  author={Robert M. Prins and Gail P. Scott and Randall Edward Merchant and Martin R. Graf},
  journal={Cancer Immunology, Immunotherapy},
  year={2002},
  volume={51},
  pages={190-199}
}
These studies report the identification of a population of myeloid suppressor cells (MSC) that are preferentially enriched in the spleens and tumor-infiltrating mononuclear cells (TIMC) from T9.F-vaccinated animals. In this model designed to mimic immunotherapy for an established intracranial (i.c.) glioma, animals were given an i.c. inoculum with 5×104 T9… CONTINUE READING