Iron toxicity in organotypic cultures of hippocampal slices: role of reactive oxygen species.

@article{Liu2003IronTI,
  title={Iron toxicity in organotypic cultures of hippocampal slices: role of reactive oxygen species.},
  author={Ruolan Liu and Wei Liu and Susan R. Doctrow and Michel Baudry},
  journal={Journal of neurochemistry},
  year={2003},
  volume={85 2},
  pages={492-502}
}
Free iron has been assumed to potentiate oxygen toxicity by generating reactive oxygen species (ROS) via the iron-catalyzed Haber-Weiss reaction, leading to oxidative stress. ROS-mediated iron cytotoxicity may trigger apoptotic cell death. In the present study, we used iron treatment of organotypic cultures of hippocampal slices to study potential mechanisms involved in iron-induced neuronal damage. Exposure of mature hippocampal slices to ferrous sulfate resulted in concentration- and time… CONTINUE READING
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