Iron toxicity in mice with collagenase-induced intracerebral hemorrhage.

  title={Iron toxicity in mice with collagenase-induced intracerebral hemorrhage.},
  author={He Min Wu and Tao Wu and Xueying Xu and Jessica Wang and Jian Wang},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={31 5},
Intracerebral hemorrhage (ICH) is a devastating form of stroke. In this study, we examined the efficacy of deferoxamine (DFX), an iron chelator, after collagenase-induced ICH in 12-month-old mice. Intracerebral hemorrhage was induced by intrastriatal injection of collagenase. Deferoxamine (200  mg/kg, intraperitoneal) or vehicle was administrated 6  hours after ICH and then every 12  hours for up to 3 days. Neurologic deficits were examined on days 1 and 3 after ICH. Mice were killed after 1 or… CONTINUE READING


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