Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1.

@article{Nuez2010IronSD,
  title={Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1.},
  author={Marco T. Nu{\~n}ez and Victoria Tapia and Alejandro Rojas and Pabla Aguirre and Francisco Gomez and Francisco Nualart},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={298 3},
  pages={
          C477-85
        }
}
Intestinal iron absorption comprises the coordinated activity of the influx transporter divalent metal transporter 1 (DMT1) and the efflux transporter ferroportin (FPN). In this work, we studied the movement of DMT1 and FPN between cellular compartments as a function of iron supply. In rat duodenum, iron gavage resulted in the relocation of DMT1 to basal domains and the internalization of basolateral FPN. Considerable FPN was also found in apical domains. In Caco-2 cells, the apical-to-basal… CONTINUE READING

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