Iron-sulfur-protein biogenesis in eukaryotes.

  title={Iron-sulfur-protein biogenesis in eukaryotes.},
  author={Roland Lill and Ulrich M{\"u}hlenhoff},
  journal={Trends in biochemical sciences},
  volume={30 3},
Iron-sulfur (Fe-S) clusters (ISCs) are versatile, ancient co-factors of proteins that are involved in electron transport, enzyme catalysis and regulation of gene expression. The synthesis of ISCs and their insertion into apoproteins involves the function of complex cellular machineries. In eukaryotes, the mitochondrial ISC-assembly machinery is involved in the maturation of all cellular iron-sulfur proteins. A mitochondrial export machinery and a recently discovered cytosolic assembly system… CONTINUE READING
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