Iron-sulfur cluster biosynthesis. Thermatoga maritima IscU is a structured iron-sulfur cluster assembly protein.

@article{Mansy2002IronsulfurCB,
  title={Iron-sulfur cluster biosynthesis. Thermatoga maritima IscU is a structured iron-sulfur cluster assembly protein.},
  author={Sheref S. Mansy and Gong Wu and Kristene K. Surerus and James Allan Cowan},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 24},
  pages={21397-404}
}
Genetic evidence has indicated that Isc proteins play an important role in iron-sulfur cluster biogenesis. In particular, IscU is believed to serve as a scaffold for the assembly of a nascent iron-sulfur cluster that is subsequently delivered to target iron-sulfur apoproteins. We report the characterization of an IscU from Thermatoga maritima, an evolutionarily ancient hyperthermophilic bacterium. The stabilizing influence of a D40A substitution allowed characterization of the holoprotein. M… CONTINUE READING
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