Iron-sulfur cluster biogenesis and human disease.

@article{Rouault2008IronsulfurCB,
  title={Iron-sulfur cluster biogenesis and human disease.},
  author={Tracey A Rouault and Wing Hang Tong},
  journal={Trends in genetics : TIG},
  year={2008},
  volume={24 8},
  pages={398-407}
}
Iron-sulfur (Fe-S) clusters are essential for numerous biological processes, including mitochondrial respiratory chain activity and various other enzymatic and regulatory functions. Human Fe-S cluster assembly proteins are frequently encoded by single genes, and inherited defects in some of these genes cause disease. Recently, the spectrum of diseases attributable to abnormal Fe-S cluster biogenesis has extended beyond Friedreich ataxia to include a sideroblastic anemia with deficiency of… CONTINUE READING

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