Iron-sulfur cluster biogenesis and human disease.

  title={Iron-sulfur cluster biogenesis and human disease.},
  author={Tracey A Rouault and Wing Hang Tong},
  journal={Trends in genetics : TIG},
  volume={24 8},
Iron-sulfur (Fe-S) clusters are essential for numerous biological processes, including mitochondrial respiratory chain activity and various other enzymatic and regulatory functions. Human Fe-S cluster assembly proteins are frequently encoded by single genes, and inherited defects in some of these genes cause disease. Recently, the spectrum of diseases attributable to abnormal Fe-S cluster biogenesis has extended beyond Friedreich ataxia to include a sideroblastic anemia with deficiency of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 134 extracted citations


Publications referenced by this paper.
Showing 1-10 of 85 references

Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [ 2 Fe2 S ] clusters

  • J. Dupuy
  • EMBO J .
  • 2008

Similar Papers

Loading similar papers…