Iron-saturated lactoferrin stimulates cell cycle progression through PI3K/Akt pathway.

  title={Iron-saturated lactoferrin stimulates cell cycle progression through PI3K/Akt pathway.},
  author={Shin-Hee Lee and Chul-Woong Pyo and Dae Hyun Hahm and Jiyoung Kim and S Choi},
  journal={Molecules and cells},
  volume={28 1},
Iron binding lactoferrin (Lf) is involved in the control of cell cycle progression. However, the molecular basis underlying the effects of Lf on cell cycle control, as well as its target genes, remains incompletely understood. In this study, we have demonstrated that a relatively low level of ironsaturated Lf, Lf(Fe(3+)), can stimulate S phase cell cycle entry, and requires Akt activation in MCF-7 cells. Lf(Fe(3+)) immediately induced Akt phosphorylation at Ser473, which subsequently induced… CONTINUE READING

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