Iron release and ROS generation from mineral particles are not related to cytokine release or apoptosis in exposed A549 cells.

@article{Ovrevik2006IronRA,
  title={Iron release and ROS generation from mineral particles are not related to cytokine release or apoptosis in exposed A549 cells.},
  author={Johan Ovrevik and Ragna Bogen Hetland and Roel P. F. Schins and Theresa Myran and Per Everhard Schwarze},
  journal={Toxicology letters},
  year={2006},
  volume={165 1},
  pages={31-8}
}
The generation of reactive oxygen species (ROS) by mineral particles is believed to be central to their toxicity and their ability to induce inflammation. Surface bound or soluble iron may contribute to the particle-effects by enhancing the ROS generation through the Fenton reaction. Nevertheless, the importance of ROS and transition metals to mineral particle-induced effects is still unclear and further investigations are needed. In the present study we have investigated different mineral… CONTINUE READING
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