Iron regulatory proteins 1 and 2.

  title={Iron regulatory proteins 1 and 2.},
  author={Beric R. Henderson},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={18 9},
Iron uptake and storage in mammalian cells is at least partly regulated at a post-transcriptional level by the iron regulatory proteins (IRP-1 and IRP-2). These cytoplasmic regulators share 79% similarity in protein sequence and bind tightly to conserved mRNA stem-loops, named iron-responsive elements (IREs). The IRP:IRE interaction underlies the regulation of translation and stability of several mRNAs central to iron metabolism. The question of why the cell requires two such closely related… CONTINUE READING

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