Iron regulatory proteins, iron responsive elements and iron homeostasis.

  title={Iron regulatory proteins, iron responsive elements and iron homeostasis.},
  author={Richard S. Eisenstein and Kenneth P. Blemings},
  journal={The Journal of nutrition},
  volume={128 12},
The discovery of iron regulatory proteins (IRPs) has provided a molecular framework from which to more fully understand the coordinate regulation of vertebrate iron metabolism. IRPs bind to iron responsive elements (IREs) in specific mRNAs and regulate their utilization. The targets of IRP action now appear to extend beyond proteins that function in the storage (ferritin) or cellular uptake (transferrin receptor) of iron to include those involved in other aspects of iron metabolism as well as… CONTINUE READING


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