Iron regulatory factor expressed from recombinant baculovirus: conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase.

@article{EmeryGoodman1993IronRF,
  title={Iron regulatory factor expressed from recombinant baculovirus: conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase.},
  author={Alice Emery-Goodman and Harald Hirling and Leo Scarpellino and Brian Henderson and Lukas C. K{\"u}hn},
  journal={Nucleic acids research},
  year={1993},
  volume={21 6},
  pages={1457-61}
}
Iron regulatory factor (IRF) is a cytoplasmic mRNA-binding protein that coordinates post-transcriptionally the expression of several important proteins in iron metabolism. Binding of IRF to iron-responsive elements (IRE) in the 5' untranslated region (UTR) of ferritin and erythroid 5-aminolevulinic acid-synthase mRNAs inhibits their translation, whereas binding to IREs in the 3' UTR of transferrin receptor (TfR) mRNA prevents the degradation of this mRNA. IRF binds RNA strongly after iron… CONTINUE READING