Iron regulation by hepatocytes and free radicals

  title={Iron regulation by hepatocytes and free radicals},
  author={Taro Takami and Isao Sakaida},
  booktitle={Journal of clinical biochemistry and nutrition},
Iron is an essential metallic microelement for life. However, iron overload is toxic. The liver serves an important role as a storehouse for iron in the body. About 20-25 mg of iron is required each day for hemoglobin synthesis. To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved in the uptake of iron into hepatocytes, ferritin in its storage, and ferroportin in its export. Moreover, hepcidin controls ferroportin and plays a central role in the iron… CONTINUE READING
12 Citations
60 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 12 extracted citations


Publications referenced by this paper.
Showing 1-10 of 60 references

Similar Papers

Loading similar papers…