Iron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis.

  title={Iron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis.},
  author={Marta Zapotoczna and Simon Heilbronner and Pietro Speziale and T. J. Foster},
  journal={Journal of bacteriology},
  volume={194 23},
Staphylococcus lugdunensis is the only coagulase-negative Staphylococcus species with a locus encoding iron-regulated surface determinant (Isd) proteins. In Staphylococcus aureus, the Isd proteins capture heme from hemoglobin and transfer it across the wall to a membrane-bound transporter, which delivers it into the cytoplasm, where heme oxygenases release iron. The Isd proteins of S. lugdunensis are expressed under iron-restricted conditions. We propose that S. lugdunensis IsdB and IsdC… CONTINUE READING
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