Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

@article{Gutteridge1986IronPO,
  title={Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides},
  author={John M. C. Gutteridge},
  journal={FEBS Letters},
  year={1986},
  volume={201}
}
Peroxidation of linoleic acid induced by interaction with haemoglobin and hydrogen peroxide.
TLDR
Peroxidation of linoleic acid was found to be induced by interaction with haemoglobin and hydrogen peroxide, and was accelerated by ascorbic acid.
Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.
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  • Medicine
    British journal of experimental pathology
  • 1989
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Hydrogen and perpetuate the chain reaction of lipid peroxidation (Gutteridge) by the equations below, in which lipid* symbolises a carbon-centred radical.
The role of erythrocyte peroxiredoxin in detoxifying peroxides and in stimulating potassium efflux via the Gardos channels.
Using mice deficient in glutathione peroxidase, Johnson et al reported that this enzyme plays an important role within erythrocytes in the detoxification of organic peroxides.[1][1] The authors
Lipid peroxidation and antioxidants as biomarkers of tissue damage.
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The body has a hierarchy of defense strategies to deal with oxidative stress within different cellular compartments, and superimposed on these are gene-regulated defenses involving the heat-shock and oxidant stress proteins.
Haemoglobin and myoglobin as inhibitors of hydroxyl radical generation in a model system of "iron redox" cycle.
TLDR
The pro-oxidative or anti-Oxidative activities of haemproteins in biological oxidative reactions seem to be dependent on compartmentalization and on the presence and concentrations of reducing compounds and H2O2.
Decompartmentalised Iron, Microbleeding and Membrane Oxidation
In pathological states, current models which account for the phenomenon of oxidative stress in cells and tissues include: increased generation of oxygen radicals, modified antioxidant defences and
Iron redox reactions and lipid peroxidation.
  • S. Aust
  • Chemistry
    Basic life sciences
  • 1988
Iron redox reactions and lipid peroxidation.
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