Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years.

@article{Ferrucci1990IronOM,
  title={Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years.},
  author={Joseph T. Ferrucci and David D. Stark},
  journal={AJR. American journal of roentgenology},
  year={1990},
  volume={155 5},
  pages={943-50}
}
Superparamagnetic iron oxide (SPIO) particles are a potent new class of MR contrast agents affording improved detection of hepatic and splenic neoplasms. In this report we review the development of this agent through preclinical studies and early clinical results at Massachusetts General Hospital during a 5-year investigation. SPIO particles are sequestered by normal phagocytic Kupffer cells of the reticuloendothelial system (RES) but are not retained in tumor tissue. Consequently, there is a… CONTINUE READING
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