Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells.

@article{Park2015IronOT,
  title={Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells.},
  author={Junghyung Park and Dong Gil Lee and B Moon Kim and S Park and Jung-Hak Kim and Sang-Rae Lee and Kyu-Tae Chang and Hyun-Shik Lee and Dong-Seok Lee},
  journal={Toxicology},
  year={2015},
  volume={337},
  pages={39-46}
}
The accumulation of iron in neurons has been proposed to contribute to the pathology of numerous neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. However, insufficient research has been conducted on the precise mechanism underlying iron toxicity in neurons. In this study, we investigated mitochondrial dynamics in hippocampal HT-22 neurons exposed to ferric ammonium citrate (FAC) as a model of iron overload and neurodegeneration. Incubation with 150 μM FAC for 48… CONTINUE READING