Iron-overload-related disease in HFE hereditary hemochromatosis.

  title={Iron-overload-related disease in HFE hereditary hemochromatosis.},
  author={Katrina J Allen and Lyle C. Gurrin and Clare C. Constantine and Nicholas J Osborne and Martin B. Delatycki and Amanda J. Nicoll and Christine E. McLaren and Melanie Bahlo and Amy E Nisselle and Christopher D. Vulpe and Gregory J Anderson and Melissa C. Southey and Graham G. Giles and Dallas English and John L. Hopper and John K Olynyk and Lawrie William Powell and Dorota M. Gertig},
  journal={The New England journal of medicine},
  volume={358 3},
BACKGROUND Most persons who are homozygous for C282Y, the HFE allele most commonly asssociated with hereditary hemochromatosis, have elevated levels of serum ferritin and transferrin saturation. Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial. METHODS We assessed HFE mutations in 31,192 persons of northern European descent between the ages of 40 and 69 years who participated in the Melbourne Collaborative Cohort Study and were… CONTINUE READING


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Haemochromatosis. Lancet 2007;370:1855-60

  • PC Adams, JC Barton
  • 2007

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