Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells.

@article{Lee2016IronOC,
  title={Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells.},
  author={Dong Gil Lee and Junghyung Park and Hyun-Shik Lee and Sang-Rae Lee and Dong-Seok Lee},
  journal={Toxicology},
  year={2016},
  volume={365},
  pages={17-24}
}
Iron is necessary for neuronal functions; however, excessive iron accumulation caused by impairment of iron balance could damage neurons. Neuronal iron accumulation has been observed in several neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Nevertheless, the precise mechanisms underlying iron toxicity in neuron cells are not fully understood. In this study, we investigated the mechanism underlying iron overload-induced mitochondrial fragmentation in HT-22… CONTINUE READING
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