Iron overload in beta 2-microglobulin-deficient mice.

  title={Iron overload in beta 2-microglobulin-deficient mice.},
  author={Maria Leonor Baptista de Sousa and R Reim{\~a}o and Rosa Lacerda and Patrice Hugo and Stefan H. E. Kaufmann and Graça Porto},
  journal={Immunology letters},
  volume={39 2},
The present paper describes the results of a comparative histological and quantitative analysis of iron distribution in tissues of beta 2m-/- and beta 2m+/- mice of different ages. Progressive hepatic iron overload, indistinguishable from that observed in human hemochromatosis, was found only in mice homozygous for the mutated beta 2m gene. Total iron measurements done by flame atomic absorption showed statistically significant differences between liver samples from 5 beta 2m+/- heterozygotes… CONTINUE READING

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