Iron overload and immunity.

  title={Iron overload and immunity.},
  author={Graça Porto and Maria Leonor Baptista de Sousa},
  journal={World journal of gastroenterology},
  volume={13 35},
Progress in the characterization of genes involved in the control of iron homeostasis in humans and in mice has improved the definition of iron overload and of the cells affected by it. The cell involved in iron overload with the greatest effect on immunity is the macrophage. Intriguing evidence has emerged, however, in the last 12 years indicating that parenchymal iron overload is linked to genes classically associated with the immune system. This review offers an update of the genes and… CONTINUE READING

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