Iron mobilisation and cellular protection by a new synthetic chelator O-Trensox.

@article{Rakba1998IronMA,
  title={Iron mobilisation and cellular protection by a new synthetic chelator O-Trensox.},
  author={N. Rakba and F. Aouad and C. Henry and C. Caris and I. Morel and P. Baret and J. Pierre and P. Brissot and R. Ward and G. Lescoat and R. Crichton},
  journal={Biochemical pharmacology},
  year={1998},
  volume={55 11},
  pages={
          1797-806
        }
}
We tested a new synthetic, 8-hydroxyquinoline-based, hexadentate iron chelator, O-Trensox and compared it with desferrioxamine B (DFO). Iron mobilisation was evaluated: (i) in vitro by using ferritin and haemosiderin; DFO mobilised iron much more rapidly from ferritin at pH 7.4 than did O-Trensox, whereas at pH 4, ferritin and haemosiderin iron mobilisation was very similar with both chelators; (ii) in vitro by using cultured rat hepatocytes which had been loaded with 55Fe-ferritin; here DFO… Expand
Mobilization of iron from cells by hydroxyquinoline-based chelators.
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