Iron metabolism and the IRE/IRP regulatory system: an update.

  title={Iron metabolism and the IRE/IRP regulatory system: an update.},
  author={Kostas Pantopoulos},
  journal={Annals of the New York Academy of Sciences},
Cellular iron homeostasis is accomplished by the coordinated regulated expression of the transferrin receptor and ferritin, which mediate iron uptake and storage, respectively. The mechanism is posttranscriptional and involves two cytoplasmic iron regulatory proteins, IRP1 and IRP2. Under conditions of iron starvation, IRPs stabilize the transferrin receptor and inhibit the translation of ferritin mRNAs by binding to "iron responsive elements" (IREs) within their untranslated regions. The IRE… CONTINUE READING
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