Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death.

@article{Bresgen2010IronmediatedOS,
  title={Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death.},
  author={N. Bresgen and Heidi Jaksch and H. Lacher and I. Ohlenschl{\"a}ger and K. Uchida and P. Eckl},
  journal={Free radical biology & medicine},
  year={2010},
  volume={48 10},
  pages={
          1347-57
        }
}
Previously, we have demonstrated an apoptosis-inducing activity of an acidic, H-chain-rich isoferritin secreted from primary rat hepatocytes in vitro. Because this proapoptotic property may be responsible for the growth-inhibitory and immunosuppressive effects described for certain ferritin species, we aimed to address the mechanism by which ferritin can trigger cell death. Suggesting a pivotal role for iron, iron chelation by desferrioxamine significantly abrogates ferritin-mediated apoptosis… Expand
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