Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages.

@article{Knutson2003IronLA,
  title={Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages.},
  author={Mitchell D Knutson and Mohammad Reza Vafa and David J. Haile and Marianne Wessling-Resnick},
  journal={Blood},
  year={2003},
  volume={102 12},
  pages={4191-7}
}
The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes. To gain insight into FPN1's role in macrophage iron metabolism, we examined the effect of iron status and erythrophagocytosis on FPN1 expression in J774 macrophages. Northern analysis indicated that FPN1 mRNA levels decreased with iron depletion and increased on iron loading. The iron-induced induction of FPN1… CONTINUE READING
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