Iron load increases ferritin synthesis and secretion in adult human hepatocyte cultures.

  title={Iron load increases ferritin synthesis and secretion in adult human hepatocyte cultures.},
  author={G{\'e}rard Lescoat and N Hubert and Romain Moirand and Patrick J{\'e}go and Nicole Pasdeloup and Pierre Brissot},
  volume={11 1},
In order to determine if iron load was able to stimulate specifically ferritin synthesis and secretion in adult human hepatocytes, primary cultures were submitted to increasing concentrations of ferric iron. The following results were obtained: 1. iron incorporation within the hepatocytes increased as a function of culture time and reached a high level after 48 h of treatment; 2. a dose-dependent significant stimulation of ferritin synthesis and secretion was observed when the medium iron… Expand
Regulation of ferritin and transferrin receptor expression by iron in human hepatocyte cultures.
It was demonstrated that normal human hepatocytes in primary culture respond to iron in a manner close to that observed in vivo and thereby provide a promising experimental model for further understanding pathophysiological mechanisms involved in human hemochromatotic liver. Expand
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It is suggested that the photoreduction of ferritin and/or other iron-containing proteins plays a significant role in the UVA-induced photocytotoxicity of skin fibroblasts. Expand
Chronic alcohol abuse may lead to high skin iron content, but not to hepatic siderosis.
The general assumption that chronic alcohol abuse induces hepatic siderosis, i.e. high iron concentrations in liver tissue, has not been supported by results of the present study and anamnestic data should not be overestimated, however, there seems to exist a correlation between chronic alcohol Abuse and high iron concentration in the skin. Expand
Iron homeostasis in immune mononuclear cells : a potential role in a atherogenesis
Tese de doutoramento, Biologia (Biologia-Molecular), Universidade de Lisboa, Faculdade de Ciencias, 2015


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