Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide.


We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death. Cultured rat cardiomyocytes incubated with 20 microM iron (added as FeCl(3)-Na nitrilotriacetate, Fe-NTA) displayed hypertrophy features that included increased protein synthesis and cell size, plus realignment of F-actin… (More)
DOI: 10.1016/j.freeradbiomed.2009.11.017