Iron-induced carcinogenesis: the role of redox regulation.

  title={Iron-induced carcinogenesis: the role of redox regulation.},
  author={Shinya Toyokuni},
  journal={Free radical biology & medicine},
  volume={20 4},
Redox cycling is a characteristic of transition metals such as iron. Iron is hypothesized to have been actively involved in the birth of primitive life on earth through the generation of reducing equivalents in the presence of UV light. Iron is an essential metal in mammals for oxygen transport by hemoglobin and for the function of many enzymes including catalase and cytochromes. However, the "free" or "catalytic" form of iron mediates the production of reactive oxygen species via the Fenton… CONTINUE READING