Iron induced RNA-oxidation in the general population and in mouse tissue.

Abstract

Iron promotes formation of hydroxyl radicals by the Fenton reaction, subsequently leading to potential oxidatively generated damage of nucleic acids. Oxidatively generated damage to RNA, measured as 8-oxo-7,8-dihydroguanosine (8-oxoGuo) in urine, is increased in patients with genetic iron overload, which have led us to test the hypothesis that high iron… (More)
DOI: 10.1016/j.freeradbiomed.2017.11.013

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