Iron homeostasis and nutritional iron deficiency.

  title={Iron homeostasis and nutritional iron deficiency.},
  author={Elizabeth C. Theil},
  journal={The Journal of nutrition},
  volume={141 4},
Nonheme food ferritin (FTN) iron minerals, nonheme iron complexes, and heme iron contribute to the balance between food iron absorption and body iron homeostasis. Iron absorption depends on membrane transporter proteins DMT1, PCP/HCP1, ferroportin (FPN), TRF2, and matriptase 2. Mutations in DMT1 and matriptase-2 cause iron deficiency; mutations in FPN, HFE, and TRF2 cause iron excess. Intracellular iron homeostasis depends on coordinated regulation of iron trafficking and storage proteins… CONTINUE READING


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