Iron handling and gene expression of the divalent metal transporter, DMT1, in the kidney of the anemic Belgrade (b) rat.

@article{Ferguson2003IronHA,
  title={Iron handling and gene expression of the divalent metal transporter, DMT1, in the kidney of the anemic Belgrade (b) rat.},
  author={Carole J Ferguson and Mark Wareing and Mathieu Delannoy and Robert Fenton and Stuart J McLarnon and Nicholas W. Ashton and Alan G Cox and R. F. T. Mcmahon and Laura M. Garrick and Roger H Green and Craig P Smith and Daniela Riccardi},
  journal={Kidney international},
  year={2003},
  volume={64 5},
  pages={1755-64}
}
BACKGROUND We have previously shown that the rat kidney reabsorbs metabolically significant amounts of iron and that it expresses the divalent metal transporter 1, DMT1. The Belgrade (b) rat carries a mutation in DMT1 gene, which causes hypochromic, microcytic anemia due to impaired intestinal iron absorption and transport of iron out of the transferrin cycle endosome. In the duodenum of b/b rats, expression of DMT1 mRNA and protein is increased, suggesting a feedback regulation by iron stores… CONTINUE READING