Iron expulsion by exosomes drives ferroptosis resistance

@article{Strzyz2019IronEB,
  title={Iron expulsion by exosomes drives ferroptosis resistance},
  author={Paulina J Strzyz},
  journal={Nature Reviews Molecular Cell Biology},
  year={2019},
  volume={21},
  pages={4-5}
}
  • P. Strzyz
  • Published 20 November 2019
  • Biology
  • Nature Reviews Molecular Cell Biology
Exosomes are a route for expelling iron out of cells exposed to ferroptotic stimuli, thereby protecting them from ferroptotic cell death. 
Exosomes and ferroptosis: roles in tumour regulation and new cancer therapies
TLDR
Three pathways of exosome-mediated inhibition of ferroptosis are discussed, including the Fenton reaction; the ferroPTosis defence system; and lipid peroxidation, which contribute toward establishing effective cancer therapies.
Ferroptosis: A New Road towards Cancer Management
TLDR
The factors and molecular mechanisms with the diagrammatic illustrations of ferroptosis that have a role in the initiation and sensitivity of ferraptosis in various malignancies are reviewed to open a new road for research in oncology and cancer management.
Autophagy‐Dependent Ferroptosis as a Therapeutic Target in Cancer
TLDR
This review summarizes the specific molecular and regulatory networks of autophagy-dependent ferroptosis and highlights their physiopathological impact on various aspects of tumor cells.
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
TLDR
Opportunities to potentially use mitochondria-mediated ferroptosis as a new strategy for cancer therapy are discussed.
Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies
TLDR
A systematic summary was conducted on the key molecular mechanisms of ferroptosis and the current potential relationships of feroptosis with leukemia, lymphoma, and multiple myeloma to provide novel potential therapeutic approaches and targets for hematological malignancies.
The Potential Therapeutic Role of Mesenchymal Stem Cells-Derived Exosomes in Osteoradionecrosis
TLDR
The current knowledge of ORN and MSCExosomes is summarized and the potential application of MSC exosomes in ORN treatment is highlighted, which can promote bone regeneration therapies.
Novel insights into ferroptosis: Implications for age-related diseases
TLDR
This review discusses the direct and indirect involvement of the activation and/or inhibition of ferroptosis in the pathogenesis of some important diseases, and highlights therapeutic targets relevant for ARDs.
Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes
TLDR
The findings identify that ferroptosis contributes to the PBC loss and dysfunction and exerts beneficial effects on T2DM potentially by inhibiting pancreatic iron deposition and PBC ferroPTosis, highlighting promising control strategies of T2 DM by quercetin.
...
...

References

SHOWING 1-3 OF 3 REFERENCES
Prominin2 Drives Ferroptosis Resistance by Stimulating Multivesicular Body/Exosome-Mediated Iron Export
TLDR
It is revealed that ferroptosis resistance can be driven by a prominin2-MVB/exosome-ferritin pathway and they have broad implications for iron homeostasis, intracellular trafficking, and cancer.
Shedding light on the cell biology of extracellular vesicles
TLDR
Extracellular vesicles are now considered as an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids and genetic material.