Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity


BACKGROUND Iron dysregulation is a potential contributor to the pathology of obesity-related metabolic complications. KK/HIJ (KK) mice, a polygenic obese mouse model, have elevated serum iron levels. A subset of KK male mice display a bronzing of epididymal adipose tissue (eAT) associated with >100-fold (p<0.001) higher iron concentration. METHODS To… (More)
DOI: 10.1371/journal.pone.0179889


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