Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB

@article{Gao2019IronDL,
  title={Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB},
  author={Yan Gao and Jingfang Liu and Zhenzhong Bai and Sandy Sink and Chengyu Zhao and F. Lorenzo and D. McClain},
  journal={The Journal of Biological Chemistry},
  year={2019},
  volume={294},
  pages={5487 - 5495}
}
  • Yan Gao, Jingfang Liu, +4 authors D. McClain
  • Published 2019
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • We previously reported that iron down-regulates transcription of the leptin gene by increasing occupancy of phosphorylated cAMP response element-binding protein (pCREB) at two sites in the leptin gene promoter. Several nutrient-sensing pathways including O-GlcNAcylation also regulate leptin. We therefore investigated whether O-glycosylation plays a role in iron- and CREB-mediated regulation of leptin. We found that high iron decreases protein O-GlcNAcylation both in cultured 3T3-L1 adipocytes… CONTINUE READING

    Figures and Topics from this paper.

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 47 REFERENCES
    A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
    • 802
    Regulation of the O-Linked β-N-Acetylglucosamine Transferase by Insulin Signaling*
    • 118
    • Open Access
    Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes.
    • 94
    • Open Access
    o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells.
    • 56
    • Highly Influential
    Adipocyte iron regulates leptin and food intake.
    • 47
    • Open Access
    Modulation of transcription factor function by O-GlcNAc modification.
    • 183
    • Open Access