Iron-deficient mice fail to develop autoimmune encephalomyelitis.

@article{Grant2003IrondeficientMF,
  title={Iron-deficient mice fail to develop autoimmune encephalomyelitis.},
  author={Sharon M Grant and Jason A. Wiesinger and John L. Beard and Margherita T. Cantorna},
  journal={The Journal of nutrition},
  year={2003},
  volume={133 8},
  pages={2635-8}
}
Determinations of the effects of iron status on the immune system are complicated by the fact that microorganisms and immune cells both utilize iron. To determine the role of iron in immune function, we utilized a model [experimental autoimmune encephalomyelitis (EAE)] in which a strong antigen-specific CD4+ T-cell response develops in the absence of infection. EAE is an autoimmune disease frequently used as a model for the human disease multiple sclerosis (MS). EAE was induced in B10.PL mice… CONTINUE READING