Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.

@article{Farrow2011IronDD,
  title={Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.},
  author={Emily G Farrow and Xijie Yu and Lelia J Summers and Siobhan I. Davis and James C. Fleet and Matthew R Allen and Alexander G. Robling and Keith R. Stayrook and Victoria N. Jideonwo and Martin J. Magers and Holly J. Garringer and Ruben Vidal and Rebecca J Chan and Charles Goodwin and Siu L. Hui and Munro Peacock and Kenneth E. White},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 46},
  pages={
          E1146-55
        }
}
Autosomal dominant hypophosphatemic rickets (ADHR) is unique among the disorders involving Fibroblast growth factor 23 (FGF23) because individuals with R176Q/W and R179Q/W mutations in the FGF23 (176)RXXR(179)/S(180) proteolytic cleavage motif can cycle from unaffected status to delayed onset of disease. This onset may occur in physiological states associated with iron deficiency, including puberty and pregnancy. To test the role of iron status in development of the ADHR phenotype, WT and R176Q… CONTINUE READING
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