Iron-deficiency anemia.

@article{Camaschella2015IrondeficiencyA,
  title={Iron-deficiency anemia.},
  author={Clara Camaschella},
  journal={The New England journal of medicine},
  year={2015},
  volume={372 19},
  pages={
          1832-43
        }
}
  • C. Camaschella
  • Published 6 May 2015
  • Medicine
  • The New England journal of medicine
Iron-deficiency anemia is the most common form of anemia in the world. This article reviews the global nature of the disease, iron homeostasis in normal and iron-deficient states, clinical findings, treatment, and causes of iron-resistant iron deficiency. 

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References

SHOWING 1-10 OF 81 REFERENCES

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

It is shown that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin.

Anemia of chronic disease.

Advances in knowledge of the causes and management of the anemia of chronic disease are discussed.

Diagnosis and management of iron deficiency anemia.

Hematologic parameters predicting a response to oral iron therapy in chronic inflammation

In anemic patients with chronic inflammatory conditions, the assessment of iron status and the selection of those who may benefit from iron therapy frequently presents diagnostic

The management of iron deficiency in inflammatory bowel disease – an online tool developed by the RAND/UCLA appropriateness method

Iron deficiency is a common and undertreated problem in inflammatory bowel disease (IBD) and it is important to select patients suitable for treatment with iron antagonists for IBD.

Guideline for the laboratory diagnosis of functional iron deficiency

One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).

Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches

New data on the importance of iron deficiency in HF have become available, and a number of studies with intravenous iron have shown promising results, and this treatment approach is likely to become an attractive option for patients with HF and iron deficiency, both with and without anemia.

Iron refractory iron deficiency anemia

In patients with Matriptase-2 deficiency, serum hepcidin is inappropriately high for the low iron status and accounts for the absent/delayed response to oral iron treatment, a challenge for the clinicians and pediatricians is recognition of the disorder among iron deficiency and other microcytic anemias commonly found in pediatric patients.

Anaemia: FIND-CKD: intravenous iron in predialysis CKD

Intravenous FCM treatment to achieve a higher serum ferritin target improved patient haemoglobin levels and reduced initiation of other anaemia treatments.

A multicenter, randomized, active‐controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia

  • Jane E. OnkenDavid B. Bregman L. Goodnough
  • Medicine
    Transfusion
  • 2014
Many patients receiving oral iron for iron deficiency anemia (IDA) cannot tolerate or fail to respond to therapy, and existing intravenous (IV) iron formulations often require repeated
...